Prazosin, an antihypertensive drug undergoes hepatic metabolism so it has low bioavailability. Bioavailability of prazosin may be improved by buccal route. The objective of this work was to develop bioadhesive buccal tablets for the delivery of prazosin. Tablets were prepared by direct compression method. Screening of different bioadhesive polymers and penetration enhancers was done based on bioadhesion strength and ex-vivo diffusion. Optimization was done by 32 factorial Design. Different concentration of HPMC K4 and sodium deoxycholate were considered as independent variables. Bioadhesion strength, in- vitro release and ex-vivo release were considered as dependent variables. Optimized batch containing 40 mg HPMC K4 and 5 mg sodium deoxycholate was studied for weight variation, friability, content uniformity, surface pH, swelling index, bioadhesion strength and in-vitro and ex-vivo studies. Bioadhesion and ex-vivo studies were carried out using goat buccal mucosa. All the parameters of optimized batch were found to be in range. Surface pH was 6.91±0.01 which suggested that the formulation was non-irritant to the buccal environment. Swelling index was increased up to 73.31% at 9 h. Bioadhesion strength was found to be 27.44 g/cm2. % In-vitro drug release and Ex-vivo diffusion were found to be 92.28% and 66.49% at 12 h respectively. This result demonstrated that Prazosin tablets released drug in sustained manner.
Loading....